Chiral Molecules and Enantiomeric Excess
Supercritical Fluid Chromatography (SFC) has shown high potential for chiral separations. Short analysis times and decreased equilibration time due to low mobile phase viscosity and superior diffusion characteristics are major benefits. In addition, significant decrease of operating costs can be achieved with the Aurora Fusion A5 Evolution SFC module, since standard grade CO2 can be used instead of expensive SFC/SFE grade CO2.
A chiral molecule is a type of molecule that lacks an internal plane of symmetry and thus has a non-superimposable mirror image. The feature that is most often the cause of chirality in molecules is the presence of an asymmetric carbon atom.
In chemistry, chirality usually refers to molecules. Two mirror images of a chiral molecule are called enantiomers or optical isomers. Pairs of enantiomers are often designated as "right-" and "left-handed."
